1268691-77-5

Basic information

• Product Name: 2-(4-cyanophenyl)-1H-indole-3-carboxylic acid ethyl ester
• Synonyms: 2-(4-cyanophenyl)-1H-indole-3-carboxylic acid ethyl ester
• CAS NO: 1268691-77-5
• Molecular Weight: 290.321
• Mol File: 1268691-77-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-cyanophenyl)-1H-indole-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-cyanophenyl)-1H-indole-3-carboxylic acid ethyl ester(1268691-77-5)
• EPA Substance Registry System: 2-(4-cyanophenyl)-1H-indole-3-carboxylic acid ethyl ester(1268691-77-5)

Safety Data

• Hazardous Substances Data: 1268691-77-5(Hazardous Substances Data)

Upstream product

• 98-95-3 nitrobenzene 
• 105-07-7 4-cyanobenzaldehyde 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 26447-78-9 C-(4-cyanophenyl)-N-phenylnitrone 
• 623-26-7 terephthalonitrile 
• 90798-47-3 ethyl α-bromo-α-(2-bromophenyl)acetate 

Relevant articles and documents

Synthesis of 2,3-Disubstituted NH Indoles via Rhodium(III)-Catalyzed C-H Activation of Arylnitrones and Coupling with Diazo Compounds

A rhodium-catalyzed intermolecular coupling between arylnitrones and diazo compounds by C-H activation/[4 + 1] annulation with a C(N2)-C(acyl) bond cleavage is reported, and 2,3-disubstituted NH indoles are directly synthesized in up to a 94% yield. A variety of functional groups are applicable to this reaction to give the corresponding products with high selectivity. Compared to other previously reported Rh(III)-catalyzed synthesis of homologous series, this method is simpler, more general, and more efficient.

Tandem one-pot construction of indoles via palladium and copper-catalyzed coupling reactions of the blaise reaction intermediate

The palladium-catalyzed intramolecular N-arylation of the Blaise reaction intermediate, formed by reaction of nitriles with an in situ generated Reformatsky reagent from ethyl -bromo - (2-bromophenyl)acetate and zinc, afforded indoles in good yields. Exte