126872-55-7

Upstream product

• 107-10-8 propylamine 
• 74928-54-4 3,5-(NO2)2C6H3CONHCH(CH2CH(CH3)2)COOH 
• 99-33-2 3,5-dinitrobenoyl chloride 
• 328-39-2 LEUCINE 

Downstream Products

• 117096-15-8 (R)-N-(3,5-dinitrobenzoyl)leucine N-propylamide 
• 103794-12-3 (S)-(+)-N-(3,5-dinitrobenzoyl)leucine n-propylamide 

Relevant academic research and scientific papers

Preparation of a New Chiral Stationary Phase Based on Macrocyclic Amide Chiral Selector for the Liquid Chromatographic Chiral Separations

A new chiral stationary phase (CSP) based on macrocyclic amide receptor was prepared starting from (1R,2R)-1,2-diphenylethylenediamine. The new CSP was successfully applied to the resolution of various N-(substituted benzoyl)-α-amino amides with reasonably good separation factors and resolutions (α = 1.75 ~ 2.97 and RS = 2.89 ~ 6.82 for 16 analytes). The new CSP was also applied to the resolution of 3-substituted 1,4-benzodiazepin-2-ones and some diuretic chiral drugs including bendroflumethiazide and methylchlothiazide and metolazone. The resolution results for 3-substituted 1,4-benzodiazepin-2-ones and some diuretic chiral drugs were also reasonably good. Chirality 28:253-258, 2016.