1268826-93-2

Upstream product

• 1268827-11-7 3,3-difluoro-4-hydroxy-4-p-tolylbutan-2-one 
• 1268826-87-4 (Z)-methyl 5-(tert-butyldimethylsilyloxy)-4,4-difluoro-3-methyl-5-p-tolylpent-2-enoate 
• 1268826-77-2 4-(tert-butyldimethylsilyloxy)-3,3-difluoro-4-p-tolylbutan-2-one 

Downstream Products

• 1268827-02-6 5,5-difluoro-4-methyl-6-p-tolyl-5,6-dihydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Fluoroallylboration-olefination for the synthesis of (Z)-4,4-difluoropent- 2-enoates and 5,5-difluoro-5,6-dihydropyran-2-ones

Horner-Wadsworth-Emmons (HWE) or Still-Gennari olefination of TBS-protected 3,3-difluoro-4-hydroxy-2-ones, derived from the difluoroallylboration of aldehydes, provides the Z-isomer of 4,4,-difluoropent-2-enoates. These, upon hydrolysis, followed by Yamaguchi cyclization, afford 5,5-difluoro-4-methyl-5,6- dihydro-α-pyrones in high yields.