1268832-67-2Relevant academic research and scientific papers
Novel Fmoc-polyamino acids for solid-phase synthesis of defined polyamidoamines
Schaffert, David,Badgujar, Naresh,Wagner, Ernst
, p. 1586 - 1589 (2011)
A versatile solid-phase approach to sequence-defined polyamidoamines was developed. Four different Fmoc-polyamino acid building blocks were synthesized by selective protection of symmetrical oligoethylenimine precursors followed by introduction of a carboxylic acid handle using cyclic anhydrides and subsequent Fmoc-protection. The novel Fmoc-polyamino acids were used to construct polyamidoamines demonstrating complete compatibility to standard Fmoc reaction conditions. The straightforward synthesis of the building blocks and the high efficiency of the solid-phase coupling reactions allow the versatile synthesis of defined polycations.
