1268852-80-7Relevant academic research and scientific papers
Synthesis of 3-heteroaryloxindoles through t-BuOCl-mediated oxidation of 3-heteroarylindoles
Baroni, Marco,Lesma, Giordano,Puleio, Letizia,Sacchetti, Alessandro,Silvani, Alessandra,Zanchet, Marco
experimental part, p. 4075 - 4081 (2011/02/21)
The oxidation of 3-heteroarylindoles to the corresponding oxindoles with t-butyl hypochlorite has been investigated. Under carefully adjusted conditions, preparative scale of desired products can be achieved. Two competing pathways seem to contribute to the reaction mechanism, affording 3-heteroaryloxindoles bearing hydrogen or chlorine at C3, depending on stereoelectronic factors. The present methodology appears also generally applicable for the preparation of simple 3-aryloxindoles. Georg Thieme Verlag Stuttgart - New York.
