126889-03-0Relevant articles and documents
IMMUNOMODULATOR
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Paragraph 0059; 0063; 0079-0080, (2021/12/18)
The present application discloses an immunomodulator, and specifically discloses a compound depicted by formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound provided in the present application can bind effectively to STING and has a good agonistic action on STING protein, and exhibits a good inhibitory effect on multiple tumors. Thus, the compound provided in the present application serves as a STING agonist and can be used for treating various related conditions. The compound provided in the present invention shows a very promising prospect for application thereof in the preparation of a medicament for treating a disease associated with STING activity (in particular, a medicament for treating an inflammatory disease, an allergic disease, an autoimmune disease, an infectious disease, a cancer or a precancerous syndrome) and in the preparation of an immune adjuvant, providing a novel option for clinically screening and/or preparing drugs for diseases associated with STING activity.
Process for the preparation of thiazolecarboxylic acid chlorides
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, (2008/06/13)
Disclosed herein is a process for the preparation of a thiazolecarboxylic acid chloride represented by the following general formula (II): STR1 wherein R1 represents a hydrogen or halogen atom, a lower alkyl group, a lower alkoxy group, or a lower alkyl group substituted by a halogen atom or lower alkoxy group, and R2 represents a hydrogen atom, a lower alkyl group, or a lower alkyl group substituted by a halogen atom or lower alkoxy group, which comprises reacting a thiazolecarboxylic acid represented by the following general formula (I): STR2 wherein R1 and R2 have the same meanings as defined with respect to formula (II), with phosgene or trichloromethyl chloroformate in the presence or absence of a catalyst.
