1269140-65-9Relevant academic research and scientific papers
Synthesis of sugar-amino acid-nucleosides as potential glycosyltransferase inhibitors
Vembaiyan, Kannan,Pearcey, Jean A.,Bhasin, Milan,Lowary, Todd L.,Zou, Wei
supporting information; experimental part, p. 58 - 66 (2011/02/28)
Sugar-amino acid-nucleosides (SAAN) were synthesized to mimic glycosyl nucleotide donors based on the hypothesis that a basic amino acid may interact with carboxylate groups of the enzyme in a manner similar to the diphosphate metal ion complex. C-Glycoside analogues of the d-galactopyranose or l-arabinofuranose ring systems, and four amino acids (lysine, glutamine, tryptophan, and histidine), were chosen for this study. The targets were synthesized and tested against GlfT2, a galactofuranosyltransferase essential for cell wall galactan biosynthesis in Mycobacterium tuberculosis. The inhibition assay showed that analogues containing histidine and tryptophan are moderate inhibitors of GlfT2.
