1269142-07-5Relevant academic research and scientific papers
Stereospecific ring expansion of chiral vinyl aziridines
Brichacek, Matthew,Navarro Villalobos, Mauricio,Plichta, Alexandra,Njardarson, Jon T.
, p. 1110 - 1113 (2011/04/25)
In this report, it is demonstrated that chiral vinyl aziridines can be stereospecifically ring expanded. This synthetic approach allows controlled access to chiral 2,5-cis-or 2,5-trans-3-pyrroline products from starting materials with the appropriate aziridine geometry. Twenty three ring expansion examples, most of which feature a stereospecific cyclization, are presented.(Figure Presented)
