126917-10-0

Basic information

• Product Name: 2-FLUORO-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 2-FLUORO-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE;alpha,alpha,alpha,2-Tetrafluoro-p-toluoyl chloride;à,à,à,2-tetrafluoro-p-toluoyl chloride;2-Fluoro-4-(trifluoromethyl)benzoyl chloride 97%;2-Fluoro-4-(trifluoromethyl)benzoylchloride97%;2-Fluoro-4-(trifluoroMethyl)benzoyl chloride, 97% 1GR;2-Fluoro-4-trifluoromethyl-1-benzenecarbonyl chloride;4-Trifluoromethyl-2-fluorobenzoyl chloride
• CAS NO: 126917-10-0
• Molecular Formula: C₈H₃ClF₄O
• Molecular Weight: 226.56
• EINECS: -0
• Product Categories: Aromatic Halides (substituted);Acid Halides;Carbonyl Compounds;Organic Building Blocks;Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Trifluoromethyl;Fluorine series
• Mol File: 126917-10-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 188-189 °C(lit.)
• Flash Point: 178 °F
• Appearance: Clear colorless/Liquid
• Density: 1.5 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.389mmHg at 25°C
• Refractive Index: n20/D 1.466(lit.)
• Sensitive: Moisture Sensitive
• BRN: 4251456
• CAS DataBase Reference: 2-FLUORO-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(126917-10-0)
• EPA Substance Registry System: 2-FLUORO-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(126917-10-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 126917-10-0(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C8H3ClF4O/c9-7(14)5-2-1-4(3-6(5)10)8(11,12)13/h1-3H

Upstream product

• 115029-24-8 2-fluoro-4-(trifluoromethyl)benzoic acid 

Downstream Products

• 927672-28-4 N-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]-2-fluoro-4-trifluoromethylbenzamide 
• 138989-96-5 N-[(1R,2R)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-N-methyl-4-trifluoromethyl-benzamide 
• 126945-36-6 [(4S,5S)-5-(2,4-Difluoro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-(2-fluoro-4-trifluoromethyl-phenyl)-methanone 
• 126917-12-2 N-[(1S,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-4-trifluoromethyl-benzamide 
• 126917-23-5 [(4S,5S)-5-(4-Chloro-phenyl)-4-methyl-5-[1,2,4]triazol-1-ylmethyl-oxazolidin-3-yl]-(2-fluoro-4-trifluoromethyl-phenyl)-methanone 
• 126917-16-6 N-[(1S,2S)-2-(4-Chloro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-2-fluoro-4-trifluoromethyl-benzamide 
• 1443144-15-7 2-fluoro-N-(quinolin-8-yl)-4-(trifluoromethyl)benzamide 
• 1040724-23-9 3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrazol-5-amine 

Relevant articles and documents

Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27

GPR27 belongs, with GPR85 and GPR173, to a small subfamily of three receptors called “Super-Conserved Receptors Expressed in the Brain” (SREB). It has been postulated to participate in key physiological processes such as neuronal plasticity, energy metabolism, and pancreatic β-cell insulin secretion and regulation. Recently, we reported the first selective GPR27 agonist, 2,4-dichloro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (I, pEC50 6.34, Emax 100%). Here, we describe the synthesis and structure-activity relationships of a series of new derivatives and analogs of I. All products were evaluated for their ability to activate GPR27 in an arrestin recruitment assay. As a result, agonists were identified with a broad range of efficacies including partial and full agonists, showing higher efficacies than the lead compound I. The most potent agonist was 4-chloro-2,5-difluoro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7y, pEC50 6.85, Emax 37%), and the agonists with higher efficacies were 4-chloro-2-methyl-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7p, pEC50 6.04, Emax 123%), and 2-bromo-4-chloro-N-(4-(N-phenylsulfamoyl)phenyl)benzamide (7r, pEC50 5.99, Emax 123%). Docking studies predicted the putative binding site and interactions of agonist 7p with GPR27. Selected potent agonists were found to be soluble and devoid of cellular toxicity within the range of their pharmacological activity. Therefore, they represent important new tools to further characterize the (patho)physiological roles of GPR27.

AMIDE COMPOUND OR SALT THEREOF, AND BACTERICIDE FOR AGRICULTURAL AND HORTICULTURAL USE CONTAINING THE COMPOUND, AND METHOD OF USING THE SAME

PROBLEM TO BE SOLVED: To provide a novel bactericide for agricultural and horticultural use having excellent spreadability and diffusibility. SOLUTION: The present invention provides an amide compound produced by, for example, the following reaction formula, and a salt thereof. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

PROCESS FOR MAKING PYRIDONE AMIDES AND PRODRUGS THEREOF USEFUL AS MODULATORS OF SODIUM CHANNELS

The present application is directed to a process of preparing compounds of formula I, and intermediates thereof as well as pharmaceutically acceptable salts, wherein R2, R3, R5, R7 and X are defined herein. The