126921-19-5

Basic information

• Product Name: 1H-Indole-3-carbonylchloride, 1-methyl-
• Synonyms: 1-Methyl-1H-indole-3-carbonylchloride
• CAS NO: 126921-19-5
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.63
• Product Categories: ACIDHALIDE
• Mol File: 126921-19-5.mol
• Article Data: 35

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Indole-3-carbonylchloride, 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carbonylchloride, 1-methyl-(126921-19-5)
• EPA Substance Registry System: 1H-Indole-3-carbonylchloride, 1-methyl-(126921-19-5)

Safety Data

• Hazardous Substances Data: 126921-19-5(Hazardous Substances Data)

Usage

Uses

1-Methyl-1H-indole-3-carbonyl Chloride has been used as a reactant in the preparation of indolo[2,3-a]pyrimido[5,4-c]carbazole derivatives as anti-cancer agents.

Upstream product

• 32387-21-6 1-methyl-3-indolecarboxylic acid 
• 79-37-8 oxalyl dichloride 
• 318-54-7 2,2,2-trifluoro-1-(1-methyl-1H-indol-3-yl)ethan-1-one 
• 603-76-9 1-methylindole 
• 120-72-9 indole 
• 19012-03-4 N-methyl-3-formylindole 
• 487-89-8 Indole-3-carboxaldehyde 
• 108438-43-3 methyl 1-methyl-1H-indole-3-carboxylate 
• 942-24-5 3-methoxycarbonylindole 
• 3416-93-1 2-(4,5-Dihydro-1,3-oxazol-2-yl)aniline 

Downstream Products

• 1570135-66-8 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-1-methyl-1H-indole-3-carboxamide 

Relevant articles and documents

Salicylaldehyde-Promoted Cobalt-Catalyzed C-H/N-H Annulation of Indolyl Amides with Alkynes: Direct Synthesis of a 5-HT3 Receptor Antagonist Analogue

A cobalt-catalyzed annulation of the C(sp2)-H/N-H bond of indoloamides with alkynes assisted by 8-aminoquinoline is reported for the synthesis of six-membered indololactams. The use of salicylaldehyde as the ligand is crucial for this transformation. The protocol has a broad scope for both alkynes and indoles. Preparing an active Co complex illustrates that salicylaldehyde plays a key role in the C-H activation step. The synthetic applications are proven by the gram-scale reaction and one-step construction of the multicyclic 5-HT3 receptor antagonist.

Palladium-Catalyzed Tandem Dehydrogenative [4 + 2] Annulation of Terminal Olefins with N-Sulfonyl Amides via C-H Activations

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp2)-H activation, allylic C(sp3)-H activation, and homoallylic C(sp3)-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Preparation method for synthesizing spiro indolone based on furan and indole aryloxy bifunctionalization and application thereof

The invention discloses a preparation method for synthesizing spiro indolone based on furan and indole aryloxy bifunctionalization. An indole derivative (N-(o-bromophenyl)-3-indole formamide) which issimple and easy to synthesize is used for regioselectiv