1269232-99-6

Basic information

• Product Name: 3-Bromo-2,5-difluoroaniline
• Synonyms: 3-Bromo-2,5-difluoroaniline
• CAS NO: 1269232-99-6
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.0034664
• Mol File: 1269232-99-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 228.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.788±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.12±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2,5-difluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2,5-difluoroaniline(1269232-99-6)
• EPA Substance Registry System: 3-Bromo-2,5-difluoroaniline(1269232-99-6)

Safety Data

• Hazardous Substances Data: 1269232-99-6(Hazardous Substances Data)

Usage

Description

3-bromo-2,5-difluoroaniline is a chemical compound with the molecular formula C6H4BrF2N. It is categorized as a substituted aniline, meaning it contains a phenyl ring substituted with amino and halogen functional groups. 3-bromo-2,5-difluoroaniline is known for its ability to participate in cross-coupling reactions, which allows for the creation of diverse chemical structures.

Uses

Used in Pharmaceutical Industry:
3-bromo-2,5-difluoroaniline is used as an intermediate in the synthesis of pharmaceuticals for its specific chemical properties that make it valuable in various chemical reactions and processes, particularly in the production of complex organic molecules.
Used in Agrochemical Industry:
3-bromo-2,5-difluoroaniline is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
3-bromo-2,5-difluoroaniline is used as a key component in organic synthesis, widely utilized in research and industrial applications within the chemical industry due to its importance in creating diverse chemical structures through cross-coupling reactions.

Upstream product

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Downstream Products

• 1269233-00-2 2,5-difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer

CREB (cyclic-AMP responsive element binding protein) binding protein (CBP) is a potential target for prostate cancer treatment. Herein, we report the structural optimization of a series of 1-(indolizin-3-yl)ethan-1-one compounds as new selective CBP bromodomain inhibitors, aiming to improve cellular potency and metabolic stability. This process led to compound 9g (Y08284), which possesses good liver microsomal stability and pharmacokinetic properties (F = 25.9%). Furthermore, the compound is able to inhibit CBP bromodomain as well as the proliferation, colony formation, and migration of prostate cancer cells. Additionally, the new inhibitor shows promising antitumor efficacy in a 22Rv1 xenograft model (TGI = 88%). This study provides new lead compounds for further development of drugs for the treatment of prostate cancer.

FUSED RING COMPOUNDS

Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.