126939-27-3

Basic information

• Product Name: 4-Hydroxy Ketotifen
• Synonyms: 4-Hydroxy Ketotifen;4,9-Dihydro-4-hydroxy-4-(1-Methyl-4-piperidinyl)-;4-hydroxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one;Ketotifen EP Impurity C
• CAS NO: 126939-27-3
• Molecular Formula: C₁₉H₂₁NO₂S
• Molecular Weight: 327.44054
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 126939-27-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Hydroxy Ketotifen(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy Ketotifen(126939-27-3)
• EPA Substance Registry System: 4-Hydroxy Ketotifen(126939-27-3)

Safety Data

• Hazardous Substances Data: 126939-27-3(Hazardous Substances Data)

Usage

Uses

Ketotifen (K315100) impurity. Also, an intermediate in the synthesis of the 2-bromo derivative of Ketotifen.

Upstream product

• 5570-77-4 4-chloro-1-methylpiperidine 
• 126939-26-2 9H-1-Thia-benzo[f]azulene-4,10-dione 
• 63463-36-5 (1-methyl-4-piperidyl)magnesium chloride 
• 59743-84-9 10-methoxy-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one 
• 59743-88-3 10-methoxy-4-(1-methyl-4-piperidyl)-4H-benzo<4,5>cyclohepta<1,2-b>thiopene-4-ol 

Downstream Products

• 34580-13-7 ketotifen 

Relevant articles and documents

4H-BENZOCYLOHEPTATHIOPHENES AND 9,10-DIHYDRO DERIVATIVES-SULFONIUM ANALOGUES OF PIZOTIFEN AND KETOTIFEN; CHIRALITY OF KETOTIFEN: SYNTHESIS OF THE 2-BROMO DERIVATIVE OF KETOTIFEN

Reaction of ketone IX with 4-tetrahydrothiopyranylmagnesium bromide and the following dehydration with thionyl chloride afforded the sulfide III which was transformed to the methiodide II (sulfonium analogue of pizotifen).Similar sequence starting from ketone XXIV and concluded by dehydration of the alcohol XX, cleavage of the enol ether, and by treatment with methyl iodide resulted in the formation of the sulfonium analogue of ketotifen (V).Three modified routes leading to ketotifen (IV) are being described.The chirality of ketotifen was proven by (1)H NMR spectrscopy with the help of,optically active NMR shift reagent.The resolution of racemic ketotifen (IV) was achieved by crystallization of salts with optically active O,O'-diacyltartaric acids and homogenous anantiomers were obtained.The X-ray crystallographic analysis of (+)-IV-O,O'-di(p-toluoyl)-(R)-tartrate led to the three- dimensional structure of the molecule of (+)-ketotifen which enabled to determine its absolute configuration to be (R).One of the products of bromination of the ketone IX, the following methanolysis and dehydrobromonation, identified as XXVII, was transformed by reaction with 1-methyl-4-piperidylmagnesium chloride, by the following acid-catalyzed dehydration, and cleavage of the enol ether to the 2-bromo derivative of ketotifen XXXIV. (R)(+)-Ketotifen (IV) was found to be the more active ketotifen enantiomer but the stereoselectivity of its action is only a partial one.The 2-bromo derivative of ketotifen (XXXIV) is much less active than ketotifen in the line antihistamine activity.