1269416-97-8

Basic information

• Product Name: C₁₀H₁₁⁽²⁾HClNO₂
• Synonyms: C₁₀H₁₁⁽²⁾HClNO₂
• CAS NO: 1269416-97-8
• Molecular Weight: 214.656
• Mol File: 1269416-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₁⁽²⁾HClNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₁⁽²⁾HClNO₂(1269416-97-8)
• EPA Substance Registry System: C₁₀H₁₁⁽²⁾HClNO₂(1269416-97-8)

Safety Data

• Hazardous Substances Data: 1269416-97-8(Hazardous Substances Data)

Upstream product

• 1269417-04-0 2-[(SS,2R)-2-chloro-2-deutero-2-(4-methylphenyl)sulfinylethyl]-1,3-dioxolane 
• 1269416-95-6 C₁₆H₂₂⁽²⁾HBClNO₄ 

Relevant articles and documents

Iterative stereospecific reagent-controlled homologation using a functionalized α-chloroalkyllithium: Synthesis of cyclic targets related to epibatidine

Enantioenriched 1-chloro-2-(1,3-dioxolan-2-yl)ethyllithium was generated by PhLi initiated sulfoxide-ligand exchange and deployed in situ for sequential double stereospecific reagent-controlled homologation (StReCH) of B-(2-chloro-pyrid-5-yl) pinacol boronate. This process afforded highly functionalized contiguous stereodiad motifs (typically, % ee ≥ 98%, dr ≥ 85:15) amenable to subsequent annulative transformations as demonstrated by the concise synthesis (5-7 steps) of cyclic adducts related to the analgesic alkaloid epibatidine.