1269418-70-3Relevant academic research and scientific papers
Synthesis, antimicrobial activity and structure-activity relationship study of N,N-dibenzyl-cyclohexane-1,2-diamine derivatives
Sharma, Mukul,Joshi, Penny,Kumar, Nitin,Joshi, Seema,Rohilla, Rajesh K.,Roy, Nilanjan,Rawat, Diwan S.
experimental part, p. 480 - 487 (2011/03/19)
We report herein synthesis and antimicrobial activity of a series of N,N-dibenzyl-cyclohexane-1,2-diamine derivatives. In order to study the structure-activity relationship of substituted dibenzyl-cyclohexane-1,2-diamine derivatives, 44 structurally diverse compounds were synthesized and tested against Gram-positive and Gram-negative bacterial strains. Among them, compounds 17-20, 26, 37, 38 were found to be more active than tetracycline with MIC value ranging 0.0005-0.032 μg/mL and no hemolysis upto 1024 μg/mL in mammalian erythrocytes was observed. Some of the compounds have also shown very promising antifungal activity against Candida albicans, Candida glabrata and Geotrichum candidium.
The synthesis of some perhydrobenzimidazolinium salts and their application in Pd-Carbene catalyzed heck and suzuki reactions
Yigit, Murat
scheme or table, p. 2032 - 2042 (2009/10/10)
Novel 1,3-dialkylperhydrobenzimidazolinium chloride salts were prepared as precursors of N-heterocyclic carbenes 3a-e by reacting N, N'- dialkylcyclohexandiamine, triethyl orthoformate and ammonium chloride. The salts were characterized spectroscopically
