1269429-06-2

Upstream product

• 1269429-02-8 tert-butyl (4R,5R)-4-{4-[4-(methoxycarbonyl)phenyl]but-3-en-1-yl}-2,2-dimethyl-5-phenyl-1,3-oxazolidine-3-carboxylate 
• 1269615-25-9 methyl 4-[(5R,6R)-5-amino-6-hydroxy-6-phenylhex-1-en-1-yl]benzoate hydrochloride 
• 1269429-05-1 C₂₆H₃₇NO₃Si 
• 1190391-87-7 tert-butyl (4R,5R)-2,2-dimethyl-4-[(1E)-3-oxoprop-1-en-1-yl]-5-phenyl-1,3-oxazolidine-3-carboxylate 
• 1190391-88-8 (4R,5R)-2,2-dimethyl-4-(3-oxopropyl)-5-phenyl-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 501-53-1 benzyl chloroformate 
• 46032-98-8 (1R,2R)-2-amino-1-phenylpropane-1,3-diol 
• 1009092-91-4 tert-butyl (4R,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-oxazolidine-3-carboxylate 
• 1253-47-0 triphenyl-(4-methoxycarbonylbenzyl)phosphonium chloride 

Downstream Products

• 1269429-21-1 4-(((2S,5R)-1-(tert-butoxycarbonyl)-5-((R)-((tert-butyldimethylsilyl)oxy)(phenyl)methyl)pyrrolidin-2-yl)methyl)benzoic acid 
• 1269429-01-7 4-(((2S,5R)-1-(tert-butoxycarbonyl)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)benzoic acid 

Relevant academic research and scientific papers

Discovery of benzamides as potent human β3 adrenergic receptor agonists

The paper will describe the synthesis and SAR studies that led to the discovery of benzamide (reverse amide) as potent and selective human β3-adrenergic receptor agonist. Based on conformationally restricted pyrrolidine scaffold we discovered e

NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.