1269515-40-3

Basic information

• Product Name: 2,6-difluoro-3-(propylsulfonamido)-N-(2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)benzamide
• CAS NO: 1269515-40-3
• Molecular Weight: 472.475
• Mol File: 1269515-40-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,6-difluoro-3-(propylsulfonamido)-N-(2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-3-(propylsulfonamido)-N-(2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)benzamide(1269515-40-3)
• EPA Substance Registry System: 2,6-difluoro-3-(propylsulfonamido)-N-(2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)benzamide(1269515-40-3)

Safety Data

• Hazardous Substances Data: 1269515-40-3(Hazardous Substances Data)

Upstream product

• 149246-87-7 3-(pyridin-3-yl)-1 H-pyrazol-5-amine 
• 1269515-41-4 6-nitro-2-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidine 

Relevant articles and documents

Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-RafV600E kinase with favorable physicochemical and pharmacokinetic properties

Herein we describe a novel series of ATP competitive B-Raf inhibitors based on the pyrazolo[1,5-a]pyrimidine scaffold. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. Optimization led to the identification of compound 17, a potent, selective and orally available agent with improved physicochemical and pharmacokinetic properties.