126957-56-0

Upstream product

• 13131-02-7 1-phenyl-1H-pyridin-2-one 
• 110-86-1 pyridine 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 

Downstream Products

• 960158-46-7 6-allyl-1-phenyl-3,6-dihydro-1H-pyridine-2-thione 
• 960158-47-8 4-allyl-1-phenyl-3,4-dihydro-1H-pyridine-2-thione 
• 126957-91-3 N-(1,2-Dihydro-1-phenyl-2-pyridyliden)-p-methoxybenzolsulfonamid 
• 126957-88-8 N-(1,2-Dihydro-1-phenyl-2-pyridyliden)benzolsulfonamid 

Relevant academic research and scientific papers

Transition-metal-free multicomponent reactions involving Arynes, N-heterocycles, and Isatins

Mix and match: With isoquinoline as the nucleophilic trigger, multicomponent reactions afforded spirooxazino isoquinoline derivatives, proceeding through 1,4-dipolar intermediates. The use of pyridine as a nucleophile furnished indolin-2-one derivatives, with the reaction likely proceeding through a pyridylidene intermediate.

Transition-Metal-Free C2-Functionalization of Pyridines through Aryne Three-Component Coupling

The direct C2-functionalization of pyridines through a transition-metal-free protocol by using aryne multicomponent coupling is demonstrated. The reaction allowed a broad-scope synthesis of C2-substituted pyridine derivatives bearing the ?CF3 group in good yields with α,α,α-trifluoroacetophenones as the third component. Activated keto esters could also be employed as the third component in this formal 1,2-di(hetero)arylation of ketones. Performing the reaction under dilute conditions inhibited the competing pyridine–aryne polymerization pathway. Nucleophilic attack by the initially generated pyridylidene intermediate on the carbonyl followed by an SNAr process resembling the Smiles rearrangement affords the desired products.

SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF

The present invention relates to novel spiro-oxazine analogues of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-I Formula-II Further the invention provides transition- metal free multicomponent reaction (MCR) process for the preparation of said compounds of Formula-I and II using aryne precursor, N-substituted isatin and N-heteroaromatic compound as the nucleophile,under mild condition leading to formation of desired complex of spiro-oxazine analogues (I) and indolinone analogues (II) in high yield and selectivity.

Regioselectivity, scope, and limitations of the addition of organolithium and allylmagnesium reagents to 1H-pyridine-2-thiones; access to 3,4-, 3,6-, and 5,6-dihydropyridine-2-thiones

Organolithium and lithium allyldibutylmagnesate reagents add to readily available NH, NMe, NBn, and NPh substituted pyridine-2-thiones yielding 4- and/or 6-substituted 3,4- or 3,6-dihydropyridine-2-thiones, respectively. The regioselectivity of the additi