126965-32-0

Basic information

• Product Name: meso-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid
• Synonyms: meso-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid
• CAS NO: 126965-32-0
• Molecular Weight: 418.444
• Mol File: 126965-32-0.mol

Chemical Properties

• CAS DataBase Reference: meso-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: meso-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid(126965-32-0)
• EPA Substance Registry System: meso-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid(126965-32-0)

Safety Data

• Hazardous Substances Data: 126965-32-0(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 123-25-1 succinic acid diethyl ester 
• 289622-16-8 diethyl 2-(3,4-dimethoxybenzylidene)succinate 
• 73119-35-4 2,3-bis(3,4-dimethoxybenzylidene)butanedioic acid 
• 73119-34-3 2,3-Bis-[1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid dimethyl ester 
• 163732-93-2 2,3-bis(3,4-dimethoxybenzyl)maleic anhydride 
• 259540-45-9 (2R,3S)-1,4-bis((4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidinyl)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-dione 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 163732-95-4 meso-2,3-bis(3,4-dimethoxybenzyl)butanedioic anhydride 
• 163732-94-3 meso-2,3-diveratryl-succinic acid dimethyl ester 
• 15813-34-0 D,L-2,3-bis(3,4-dimethoxybenzyl)succinic acid 
• 126274-95-1 2-(3,4-dimethoxybenzylidene)butanedioic acid monoethyl ester 
• 42923-56-8 veratrylidene-succinic acid dimethyl ester 
• 5507-27-7 3,4-dimethoxybenzylidenesuccinic acid 

Downstream Products

• 126965-33-1 D,L-2,3-bis(3,4-dimethoxybenzyl)succinic acid anhydride 
• 163732-95-4 meso-2,3-bis(3,4-dimethoxybenzyl)butanedioic anhydride 
• 15813-34-0 D_g-threo-2.3-bis-(3.4-dimethoxy-benzyl)-succinic acid 
• 15813-34-0 (1R,2R)-1,2-bis[(3,4-dimethoxyphenyl)methyl]ethane-1,2-dicarboxylic acid 
• 10351-88-9 phyllanthin 
• 58311-18-5 (2R,3R)-2,3-bis[(3,4-dimethoxyphenyl)methyl]butane-1,4-diol 
• 10352-25-7 D_g-threo-2,3-bis-(3,4-dimethoxy-benzyl)-butanediol-(1,4) 
• 10351-88-9 (+)-phyllanthin 
• 10352-26-8 trans-3,4-bis(3,4,-dimethoxybenzyl)tetrahydrofuran 
• 876026-47-0 cis-3,4-Diveratryl-tetrahydro-furan 
• 10352-25-7 (±)-secoisolariciresinol dimethyl ether 
• 5701-82-6 2,3-bis[(3,4-dimethoxyphenyl)methyl]butane 
• 103402-11-5 racem.-1,4-bis-(toluene-4-sulfonyloxy)-2,3-diveratryl-butane 
• 103402-11-5 meso-1,4-bis-(toluene-4-sulfonyloxy)-2,3-diveratryl-butane 

Relevant articles and documents

Dicaffeoyltartaric acid analogues inhibit human immunodeficiency virus type 1 (HIV-1) integrase and hiv-1 replication at nontoxic concentrations

The human immunodeficiency virus type 1 (HIV-1) is a major health problem worldwide. In this study, 17 analogues of L-chicoric acid, a potent inhibitor of HIV integrase, were studied. Of these analogues, five submicromolar inhibitors of integrase were discovered and 13 compounds with activity against integrase at less than 10 μM were identified. Six demonstrated greater than 10-fold selectivity for HIV replication over cellular toxicity. Ten analogues inhibited HIV replication at nontoxic concentrations. Alteration of the linkages between the two biscatechol rings, including the use of amides, mixed amide esters, cholate, and alkyl bridges, was explored. Amides were as active as esters but were more toxic in tissue culture. Alkyl and cholate bridges were significantly less potent against HIV-1 integrase in vitro and were inactive against HIV-1 replication. Two amino acid derivates and one digalloylderivative of L-chicoric acid (L-CA) showed improved selectivity over L-CA against integration in cell culture. These data suggest that in addition to the bis-catechols and free carboxylic acid groups reported previously, polar linkages are important constituents for optimal activity against HIV-1 integrase and that new derivatives can be developed with increased specificity for integration over HIV entry in vivo.

Oxidative Homocoupling of Chiral 3-Arylpropanoic Acid Derivatives. Application to Asymmetric Synthesis of Lignans

The oxidative homocouplings of lithium enolates of (4S)-3-(3-arylpropanoyl)-4-isopropyl-2-oxazolidinones and (4R,5S)-1-(3-arylpropanoyl)-3,4-dimethyl-5-phenyl-2-imidazolidinones gave the corresponding R,R-dimers stereoselectively with TiCl4, Ph

Asymmetric synthesis of a lignan lactone from a meso anhydride

The synthesis of a meso-2,3-dibenzylbutanedioic acid anhydride is given. Reaction of this with (+)-α-methylbenzylamide proceeds diastereoselectively to give a butanedioic acid monoamide which is converted into an enantiomerically enriched cis-2,3-dibenzyl

Asymmetric synthesis of a lignan lactone from a meso anhydride

Reaction of the anhydride of a meso-2,3-dibenzylbutanedioic acid with (+)-α-methylbenzylamine proceeds diastereoselectively to give an acid-amide which can be converted into an enantiomerically enriched cis-2,3-dibenzylbutyrolactone.