1269702-96-6

Basic information

• Product Name: 4-CHLORO-1-(3-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE
• Synonyms: 4-CHLORO-1-(3-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE
• CAS NO: 1269702-96-6
• Molecular Formula: C11H6ClFN4
• Molecular Weight: 248.64
• Mol File: 1269702-96-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-1-(3-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1-(3-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE(1269702-96-6)
• EPA Substance Registry System: 4-CHLORO-1-(3-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE(1269702-96-6)

Safety Data

• Hazardous Substances Data: 1269702-96-6(Hazardous Substances Data)

Upstream product

• 51516-71-3 5-amino-1-(3-fluorophenyl)-1H-pyrazole-4-carbonitrile 

Relevant articles and documents

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS

The present invention relates generally to inhibitors of the kinases and more particularly to novel pyrazolopyrimidine compounds.