1269755-67-0 Usage
Chemical structure
A piperidine ring with a carboxylic acid group, a benzyloxycarbonyl protecting group, and a trifluoromethyl substitution.
Potential applications
Medicinal chemistry and pharmaceuticals due to the trifluoromethyl substitution enhancing drug potency and bioavailability.
Role in organic synthesis
Precursor compound, as the benzyloxycarbonyl group is commonly used for protection and deprotection of amines during chemical reactions.
Fluorine substitution
Presence of a trifluoromethyl group, which is known to improve the properties of a compound, such as increasing its metabolic stability and lipophilicity.
Protecting group
The benzyloxycarbonyl group serves as a temporary protective shield for the amine functional group during chemical reactions, preventing unwanted side reactions.
Synthesis
The compound is likely synthesized through a series of chemical reactions, involving the formation of the piperidine ring, introduction of the carboxylic acid group, and attachment of the benzyloxycarbonyl and trifluoromethyl groups.
Deprotection
The benzyloxycarbonyl group can be removed under specific reaction conditions, allowing for further functionalization or modification of the molecule.
Structural diversity
The presence of multiple functional groups and substitutions allows for a wide range of possible derivatives and analogs, which can be explored for various biological activities and applications.
Drug development
The compound's properties make it a promising candidate for further research and development in the field of drug discovery, particularly for targeting specific biological receptors or enzymes.
Safety and toxicity
As with any chemical compound, the safety and toxicity of 1-(benzyloxycarbonyl)-6-(trifluoromethyl)piperidine-3-carboxylic acid should be carefully evaluated before its use in pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1269755-67-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,9,7,5 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1269755-67:
(9*1)+(8*2)+(7*6)+(6*9)+(5*7)+(4*5)+(3*5)+(2*6)+(1*7)=210
210 % 10 = 0
So 1269755-67-0 is a valid CAS Registry Number.
1269755-67-0Relevant academic research and scientific papers
N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES
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Page/Page column 177, (2012/08/08)
The present invention provides a compound of general formula:wherein Z2-Z6 include one or two nitrogen atoms as described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds.
N-ACYL PYRIMIDINE BIARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS
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Page/Page column 220, (2012/08/08)
The present invention provides a compound of the general formula (1): wherein one of X and Y is N and the other is an optionally substituted carbon atom, and Z2-Z5 represent one or two nitrogen atoms, as further described herein, including pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals and as components of pharmaceutical compositions. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds described herein or pharmaceutical compositions comprising such compounds.
HETEROARYL COMPOUNDS AS KINASE INHIBITORS
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, (2011/04/14)
The present invention provides a compound of Formula (I): and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor
PYRAZINYLPYRIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
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Page/Page column 104, (2011/04/14)
The present invention provides a compound of Formula (I) and pharmaceutically acceptable salts thereof. Also provided is a method of using a compound of Formula I for treating a disease or condition mediated by a CDK inhibitor.
