1269765-83-4Relevant academic research and scientific papers
An enantioselective synthesis of the resorcylic acid lactone L-783,277 via addition of an acetylide anion to a tethered weinreb amide
Lin, Andrew,Willis, Anthony C.,Banwell, Martin G.
, p. 313 - 318 (2011/04/16)
Treatment of the terminal acetylene 12, readily obtained from the previously reported acid 10, with LiHMDS resulted in a novel macrocyclization reaction to give the cycloalkyne 13. Subjection of compound 13 to hydrogenation under Lindlar-type conditions afforded the Z-configured enone 14 that could be converted into the resorcylic acid lactone 4 upon treatment with BCl3 in CH2Cl2 at -78°C. The Japan Institute of Heterocyclic Chemistry.
