1269790-93-3Relevant academic research and scientific papers
A highly selective turn-on colorimetric, red fluorescent sensor for detecting mobile zinc in living cells
Du, Pingwu,Lippard, Stephen J.
, p. 10753 - 10755 (2010)
We describe ZRL1, a turn-on colorimetric and red fluorescent zinc ion sensor. The Zn2+-promoted ring opening of the rhodamine spirolactam ring in ZRL1 evokes a 220-fold fluorescence turn-on response. In aqueous media, ZRL1 turn-on luminescence is highly selective for Zn2+ ions, with no significant response to other competitive cations, including Na+, K+, Ca2+, Mg2+, Mn2+, Fe 2+, Co2+, Ni2+, Cu2+, Cd 2+, or Hg2+. In addition to these characteristics, preliminary results indicate that ZRL1 can be delivered to living cells and can be used to monitor changes in intracellular Zn2+ levels.
