126983-79-7Relevant academic research and scientific papers
ADDITION OF 2-(PHENOXYMETHYL)-2-PROPENYLMAGNESIUM CHLORIDE TO EPOXIDES FOLLOWED BY Pd(0)-CATALYZED CYCLIZATION: A ONE-POT SYNTHESIS OF 3-METHYLENETETRAHYDROPYRANS
Louw, J. van der,Out, G. J. J.,Baan, L. van der,Kanter, F. J. J. de,Bickelhaupt, F.,Klumpp, G. W.
, p. 4863 - 4866 (1989)
Addition of 2-(phenoxymetrhyl)-2-propenylmagnesium chloride to epoxides afforded the ring opening products 3 which were converted by Pd(0) to 3-methylenetetrahydropyrans 4.
A [3 + 3] annelation approach to (+)-rhopaloic acid B
Brioche, Julien C. R.,Goodenough, Katharine M.,Whatrup, David J.,Harrity, Joseph P. A.
, p. 3941 - 3943 (2008/02/11)
A general and enantiospecific [3 + 3] reaction toward functionalized pyrans is reported that has been employed in the first enantioselective synthesis of (+)-rhopaloic acid B.
Addition of 2-(chloromagnesiomethyl)-2-alkenyl ethers to epoxides followed by Pd(0)-catalyzed cyclization: A one-pot synthesis of 3-methylenetetrahydropyrans
Van Der Louw,Van Der Baan,Out,De Kanter,Bickelhaupt,Klumpp
, p. 9901 - 9916 (2007/10/02)
Addition of 2-(chloromagnesiomethyl)-2-propenyl ethers 1a and 1b to epoxides 3 affords ring opening products 6 or 7 which are converted by Pd(0) to 3-methylenetetrahydropyrans 9. Cyclization of the addition products is best effected by a catalyst system generated in situ from Pd(OAc)2 and (i-PrO)3P.
