Periplocymarin, a cardiac glycoside compound, is derived from the Periploca sepium plant and has been traditionally utilized in Chinese medicine for treating a variety of conditions such as rheumatism, edema, and heart diseases. It functions by inhibiting the sodium-potassium pump in cells, which results in elevated intracellular calcium levels. The dual nature of its therapeutic and toxic effects makes periplocymarin a significant candidate for the development of new drugs. Moreover, it has shown potential anti-cancer properties, attracting interest for further research.
127-32-2
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Basic information
- Product Name: Periplocymarin
- Synonyms: Periplocymarin;3β-(3-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyloxy)-5,14-dihydroxy-5β-cardanolide-20(22)-ene;3β-[(2,6-Dideoxy-3-O-methyl-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-5β-card-20(22)-enolide;3β-[(3-O-Methyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-5β-card-20(22)-enolide
- CAS NO:127-32-2
- Molecular Formula: C30H46O8
- Molecular Weight: 534.68144
- EINECS: N/A
- Product Categories: N/A
- Mol File: 127-32-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: 1.582
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Periplocymarin(CAS DataBase Reference)
- NIST Chemistry Reference: Periplocymarin(127-32-2)
- EPA Substance Registry System: Periplocymarin(127-32-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 127-32-2(Hazardous Substances Data)
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127-32-2 Usage
Uses
Used in Traditional Chinese Medicine:Periplocymarin is used as a therapeutic agent for treating conditions such as rheumatism, edema, and heart diseases due to its ability to inhibit the sodium-potassium pump and increase intracellular calcium levels.
Used in Pharmaceutical Development:
Periplocymarin is used as a compound of interest in the development of new drugs, given its potential therapeutic effects and the need to manage its toxic properties.
Used in Cancer Research:
Periplocymarin is used as a subject of study in cancer research for its potential anti-cancer properties, with the aim of exploring its application in oncology and developing novel cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 127-32-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.Calculate Digit Verification of CAS Registry Number 127-32:
(5*1)+(4*2)+(3*7)+(2*3)+(1*2)=42
42 % 10 = 2
So 127-32-2 is a valid CAS Registry Number.
InChI:InChI=1/C30H46O8/c1-17-26(32)23(35-4)14-25(37-17)38-19-5-9-27(2)21-6-10-28(3)20(18-13-24(31)36-16-18)8-12-30(28,34)22(21)7-11-29(27,33)15-19/h13,17,19-23,25-26,32-34H,5-12,14-16H2,1-4H3/t17-,19?,20-,21+,22-,23+,25+,26-,27-,28-,29?,30+/m1/s1
127-32-2Upstream product
127-32-2Downstream Products
127-32-2Related news
A validated LC–MS/MS assay for the simultaneous determination of periplocin and its two metabolites, Periplocymarin (cas 127-32-2) and periplogenin in rat plasma: Application to a pharmacokinetic study09/09/2019
A sensitive and reliable LC–MS/MS method was developed and validated for the simultaneous determination of periplocin and its two metabolites (periplocymarin and periplogenin) in rat plasma using psoralen as the internal standard (IS). After liquid–liquid extraction with ethyl acetate, chromat...detailed
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Periplocymarin
