127-67-3 Usage
Description
The leaves of Pilocarpus Jaborandi contain this alkaloid but not those of P.
microphyllus. The alkaloid is a viscous oil which decomposes on attempted
distillation. It has [α]20D + 81.3° (H20) falling to + 35.2° on the addition of
alkali. The salts are well crystallized and include the hydrochloride which has
[α]~O + 72° (H20); nitrate, m.p. 137°C; [α]20D + 73.2° (H20); aurichloride, m.p.
125 C and the platinichloride tetrahydrate, m.p. 187°C (dry, dec.). In contrast
to the corresponding salts of pilocarpine and isopilocarpine (q.v.) the picrate is a
non-crystallizable oil. When heated with alkalies, the salts evolve dimethylamine
and on treatment with alcoholic sodium methoxide, the base gives isopilocarpidine, characterized as the nitrate, m.p. 109-111 °C. The latter, on quaternary
methylation furnishes isopilocarpine metho-salts, e.g. the methopicrate, m.p.
119-120°C.
References
Harnack., Annalen, 238,230 (1887)
Jowett., J. Chem. Soc., 77,474 (1900)
Burtles, Pyman, Roylance., ibid, 127,581 (1925)
Spath, Kunz., Ber., 58,513 (1925)
Preobrashenski et al., ibid, 69, 1837 (1936)
Check Digit Verification of cas no
The CAS Registry Mumber 127-67-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 127-67:
(5*1)+(4*2)+(3*7)+(2*6)+(1*7)=53
53 % 10 = 3
So 127-67-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O2/c1-2-9-7(5-14-10(9)13)3-8-4-11-6-12-8/h4,6-7,9H,2-3,5H2,1H3,(H,11,12)