127001-72-3Relevant academic research and scientific papers
Simple, Catalytic Enantioselective Syntheses of Estrone and Desogestrel
Hu, Qi-Ying,Rege, Pankaj D.,Corey
, p. 5984 - 5986 (2007/10/03)
Highly enantioselective and very short syntheses of the bioactive forms of estrone (3) and desogestrel (4) are described using a chiral oxazaborolidinium catalyst (2) in the key initial step. Enantiomerically pure estrone was synthesized in eight steps from the readily available starting materials diene 5 and α,β-enal 6 via intermediates 8 and 9. Desogestrel was synthesized using a similar strategy from diene 5 and α,β-enal 11 via intermediates 12-17. The efficient syntheses of the chiral catalyst 2 and its enantiomer are also presented. Copyright
(+)-1(S),5(R),8(S)-8-PHENYL-2-AZABICYCLOOCTAN-8-OL N,O-METHYLBORONATE (2) AND ITS ENANTIOMER, CHIRAL CHEMZYMES WHICH SERVE AS CATALYSTS FOR THEIR OWN ENANTIOSELECTIVE SYNTHESIS
Corey, E. J.,Chen, C.-P.,Reichard, Gregory A.
, p. 5547 - 5550 (2007/10/02)
An efficient synthesis of (+)-1(S),5(R),8(S)-8-phenyl-2-azabicyclooctan-8-ol (1) and its enantiomer is described.The B-methyloxaborolidine derivatives (2) of these amino alcohols are excellent catalysts (chemzymes) for the enantioselective reductio
