1270018-18-2

Upstream product

• 1260242-23-6 (2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1270018-20-6 (2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(methoxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1270018-25-1 (2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(methylthiomethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1270018-29-5 (2R,3S,4R,5R,6S)-2-((2H-tetrazol-2-yl)methyl)-6-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1270018-33-1 (2S,3R,4S,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-methyl-tetrahydro-2H-pyran-3,4,5-triol 
• 1270018-23-9 (2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(iodomethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1270018-22-8 (2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(fluoromethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1270018-35-3 (2S,3R,4R,5S,6S)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(methylsulfonylmethyl)-tetrahydro-2H-pyran-3,4,5-triol 

Relevant academic research and scientific papers

THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.