1270038-98-6Relevant articles and documents
Asymmetric syntheses of highly functionalized bicyclo [2.2.2] octene derivatives
Iwatsu, Masafumi,Urabe, Daisuke,Inoue, Masayuki
, p. 491 - 504 (2013/08/23)
Highly functionalized bicyclo[2.2.2]octene derivatives bearing two quaternary carbon centers were synthesized in an asymmetric fashion. The key transformations were the regioselective Diels-Alder reaction between 3,6-dimethyl-o-quinone monoacetal and 1,1-diethoxyethylene and the subsequent enzymatic resolution. The optically active bicyclo[2.2.2]octene derivatives obtained should serve as versatile chiral building blocks for highly functionalized natural products such as ryanodine. The Japan Institute of Heterocyclic Chemistry.