127017-78-1Relevant articles and documents
NOVEL PROCESS FOR THE PREPARATION OF 4-ARYL-3-HYDROXYMETHYL-1-METHYLPIPERIDINES.
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Page 63, (2010/02/07)
A novel, improved, and general process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines is disclosed in the present invention. 4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine is a well-known intermediate in making the anti-depressan
Method of treating calcium overload
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, (2008/06/13)
Novel piperidine compounds having the formula STR1 wherein R3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more halogen, C1-6 -alkoxy, optionally substituted aryloxy or aryl-C1-6 -alkoxy, cyano, mono or poly halogenated C1-6 -alkyl, C1-6 -alkenyl, C1-6 -alkyl, C3-5 -alkylene or trifluoromethyl groups, R1 is straight or branched C1-8 -alkyl unsubstituted or substituted with one or more cyano, ester, dialkylamino, hydroxy, amido, halogeno, substituted or unsubstituted piperidino, morpholino, thiomorpholino, dioxolanyl, tetrahydrofuranyl, C1-8 -alkoxy or C3-8 cycloalkyl groups, X is hydrogen, halogen, trifluoromethyl, hydroxy cyano or C1-8 -alkoxy, Y is O or S; provided that R1 is not unsubstituted C1-8 -alkyl, when R3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl optionally subsituted with one or more C1-6 -alkyl, C1-6 -alkoxy, C3-5 -alkylene, C3-8 -cycloalkyl or aralkoxy, and at the same time X is hydrogen or halogen and a salt thereof with a pharmaceutically acceptible acid. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.