127020-07-9Relevant academic research and scientific papers
Synthesis of oxime-based CO-releasing molecules, CORMs and their immobilization on maghemite nanoparticles for magnetic-field induced CO release
Meyer, Hajo,Brenner, Markus,H?fert, Simon-P.,Knedel, Tim-O.,Kunz, Peter C.,Schmidt, Annette M.,Hamacher, Alexandra,Kassack, Matthias U.,Janiak, Christoph
, p. 7605 - 7615 (2016)
Oxime-based CO-releasing molecules (oximeCORMs) were immobilized with a catechol-modified backbone on maghemite iron oxide nanoparticles (IONPs) to give oximeCORM@IONP. The CO release from the free and immobilized oximeCORMs was measured using the standard myoglobin assay. The oximeCORM-nanoparticles were coated with dextran for improved water solubility and confined into an alginate shell for protection and separation from the surrounding myoglobin assay to allow for CO release studies by UV/Vis absorption without interference from highly-absorptive oximeCORM@IONP. Half-lifes of the oxime-based polymer-confined alginate@dextran@oximeCORM@IONPs were estimated at 20 °C to 814 ± 23 min, at 37 °C to 346 ± 83 min and at 50 °C to 73 ± 1 min. The alginate@dextran@oximeCORM@IONP composite showed a further decrease of the half-life of CO release to 153 ± 27 min at 37 °C through local magnetic heating of the susceptible iron oxide nanoparticles with application of an external alternating magnetic field (31.7 kA m-1, 247 kHz, 39.9 mTesla). The activation energy for the CO release from molecular dicarbonylchlorido(imidazole-2-carbaldehydeoxime)(alkoxycarbonyl)ruthenium(ii) complexes is determined to be ～100 kJ mol-1 for five different imidazole-oxime derivatives.
Iodine(III)-Mediated [3 + 2] cyclization for one-pot synthesis of benzo[ d ]isoxazole-4,7-diols in aqueous medium
Hou, Yingwei,Lu, Shichao,Liu, Gang
, p. 8386 - 8395 (2013/09/24)
A one-pot [3 + 2] cycloadditive synthesis of benzo[d]isoxazole-4,7-diols in aqueous medium was carried out via nitrile oxides and benzoquinone intermediates by taking advantage of iodobenzene diacetate as an oxidant. This method can also be used to synthesize benzodiisoxazole-4,8-diols, isoxazolo[5,4-a]phenazines, and indazole-4,7-diols, which are difficult to obtain by classical methods.
NMR characterization of hydrate and aldehyde forms of imidazole-2- carboxaldehyde and derivatives
Lazaro Martinez, Juan Manuel,Romasanta, Pablo Nicolas,Chattah, Ana Karina,Buldain, Graciela Yolanda
supporting information; experimental part, p. 3208 - 3213 (2010/08/19)
The existence and stability of the aldehyde-hydrate form of imidazole-2-carboxaldehyde (4) were studied using FTIR together with solution- and solid-state NMR experiments. The results allowed us to conclude that the hydrate form was stable and precipitate
Synthesis and ocular effects of imidazole nitrolic acids
Oresmaa, Larisa,Kotikoski, Hanna,Haukka, Matti,Salminen, Johanna,Oksala, Olli,Pohjala, Esko,Moilanen, Eeva,Vapaatalo, Heikki,Vainiotalo, Pirjo,Aulaskari, Paula
, p. 4231 - 4236 (2007/10/03)
Novel 1-R-imidazole-2-nitrolic acids and 1-R-imidazole-5-nitrolic acids (R: H, Me, Bn) were synthesized from oximes by treatment with a mixture of fuming nitric acid and acetic acid. The effects of these potential nitric oxide-donating compounds were test
