127022-47-3

Basic information

• Product Name: 2-Propenoic acid, 2-[[(methoxycarbonyl)amino]methyl]-, methyl ester
• Synonyms: 2-Propenoic acid, 2-[[(methoxycarbonyl)amino]methyl]-, methyl ester
• CAS NO: 127022-47-3
• Molecular Formula: C7H11NO4
• Molecular Weight: 0
• Mol File: 127022-47-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, 2-[[(methoxycarbonyl)amino]methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-[[(methoxycarbonyl)amino]methyl]-, methyl ester(127022-47-3)
• EPA Substance Registry System: 2-Propenoic acid, 2-[[(methoxycarbonyl)amino]methyl]-, methyl ester(127022-47-3)

Safety Data

• Hazardous Substances Data: 127022-47-3(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

Chemoselectivity control in the reactions of 1,2-cyclic sulfamidates with amines

Although 1,2-cyclic sulfamidates derived from α-methylisoserine undergo nucleophilic displacement at the quaternary center, to the best of our knowledge their behavior with amines as nucleophiles has never been explored. We have found that a broad range of amines can be used, demonstrating the scope of the reaction, and that excellent control of the chemoselectivity can be achieved. Application of this methodology for the synthesis of a chiral α,β-diamino acid and an important piperazinone heterocycle is also presented. Additionally, we have found that DMF and DMSO behave not only as polar aprotic solvents but also as O-nucleophilic reagents, allowing the incorporation of an oxygen atom at a quaternary center of the electrophile, with inversion of configuration. Copyright

SN2 vs. E2 on quaternary centres: An application to the synthesis of enantiopure β2,2-amino acids

SN2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure α,α-disub

Palladium(0)-Catalyzed Amination of Allylic Acetate with Methyl Carbamate

Methyl sodiocarbamate, a recalcitrant nucleophile toward ?-allylpalladium intermediate, was found to react with allylic acetates to give allylic carbamates in the presence of a catalytic amount of Pd(PPh3)4 in THF-DMSO mixed solvent.