127024-32-2Relevant articles and documents
Candida antarctica lipase A - A powerful catalyst for the resolution of heteroaromatic β-amino esters
Solymar, Magdolna,Fueloep, Ferenc,Kanerva, Liisa T.
, p. 2383 - 2388 (2002)
Enantioselective acylations of 3-amino-3-heteroarylpropanoates (ArCH(NH2)CH2CO2Et; Ar=2- or 3-thienyl or -furyl) were performed in the presence of Candida antarctica lipase A. As a result of the excellent chemo- and enantioselectivities (E >100), gram-scale resolutions were carried out in ethyl butanoate. The hydrochloride salts of the unreacted R substrates and the butanamides of the reactive S enantiomers were thus prepared.