127040-01-1 Usage
General Description
Troglitazone glucuronide is a metabolite of the drug troglitazone, which was previously used to treat type 2 diabetes but was withdrawn from the market due to its potential for liver toxicity. Troglitazone glucuronide is formed in the liver through the process of glucuronidation, in which a glucuronic acid molecule is added to the parent compound to facilitate its excretion from the body. This metabolite is less pharmacologically active than troglitazone itself, but it is still considered important in the overall metabolism and elimination of the drug. The formation and elimination of troglitazone glucuronide from the body may have implications for the safety and efficacy of troglitazone therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 127040-01-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,0,4 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 127040-01:
(8*1)+(7*2)+(6*7)+(5*0)+(4*4)+(3*0)+(2*0)+(1*1)=81
81 % 10 = 1
So 127040-01-1 is a valid CAS Registry Number.
127040-01-1Relevant articles and documents
Studies on hindered phenols and analogues. V. Synthesis, identification and antidiabetic activity on the glucuronide of CS-045
Yoshioka,Aizawa,Fujita,Nakamura,Sasahara,Kuwano,Kinoshita,Horikoshi
, p. 2124 - 2125 (2007/10/02)
The glucuronide of a new oral antidiabetic agent, (±)-5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]thi azolidine-2,4-dione (CS-045) (1), was synthesized to confirm the structure of a metabolite in monkeys (Macaca fassicularis) and to exa
