1270569-73-7Relevant academic research and scientific papers
Asymmetric synthesis of crispine A: Constructing tetrahydroisoquinoline scaffolds using pummerer cyclizations
Rotte, Sateesh Chandra Kumar,Chittiboyina, Amar G.,Khan, Ikhlas A.
, p. 6355 - 6360 (2013/10/21)
For the first time, a concise, linear and stereoselective synthesis of both enantiomers of the natural product crispine A has been achieved in six steps with an overall yield of ≥ 20 %, starting from commercially available veratraldehyde. Asymmetric Keck allylation and trifluoroacetic anhydride-mediated Pummerer cyclization were the key transformations used to construct the tetrahydroisoquinoline core structure. Copyright
