1270882-07-9

Usage

Uses

Used in Pharmaceutical Research:
(5-bromo-N-phenyl)picolinamide is used as a building block for the development of new drugs and biologically active molecules. Its structure and the presence of a bromine atom and a phenyl group contribute to its potential applications in creating novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (5-bromo-N-phenyl)picolinamide serves as a key component in the creation of diverse chemical products and materials. Its unique structure and properties allow for its use in various chemical reactions, leading to the synthesis of a wide range of compounds.
Used in Medicinal Chemistry:
(5-bromo-N-phenyl)picolinamide is utilized as a valuable tool in medicinal chemistry, where it aids in the design and synthesis of new drug candidates. Its chemical reactivity and pharmacological potential make it a promising starting point for the development of innovative therapeutics.

Upstream product

• 30766-11-1 5-bromoisonicotinic acid 
• 62-53-3 aniline 
• 624-28-2 2,5-dibromopyridine 

Downstream Products

• 1419603-10-3 methyl 2-(6-(phenylcarbamoyl)pyridin-3-yl)propanoate 
• 1575753-51-3 C₁₆H₁₆BrN₃O₂ 

Relevant academic research and scientific papers

N2-carbamylaryl-2-aminopyrimidine derivative and medical application thereof

The invention provides an N2-carbamylaryl-2-aminopyrimidine derivative and a medical application thereof. The N2-carbamylaryl-2-aminopyrimidine derivative provided by the invention comprises an optical isomer of the N2-carbamylaryl-2-aminopyrimidine derivative and pharmaceutically acceptable salt thereof. Pharmacodynamic research shows that the traditional Chinese medicine composition has no toxicor side effect, the compound has an FLT3 inhibitory activity. The proliferation inhibition activity is realized on various leukemia cell strains; a medium inhibition effect is achieved on breast cancer cells; moreover, the polypeptide is effective for multiple mutations of AML, such as internal tandem repeat mutation of a near-membrane structural domain and D835 point mutation of an activated ring in a kinase structural domain, almost has no inhibition effect on c-KIT, can overcome drug resistance brought by clinical point mutation, can reduce toxic and side effects of bone marrow inhibition,and can be applied to preparation of antitumor drugs. The structures of the general formulas Ia and Ib of the N2-carbamylaryl-2-aminopyrimidine derivative are shown in the specification,

Copper-catalyzed carboxamide-directed ortho amination of anilines with alkylamines at room temperature

In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.

SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands

Substituted heteroaromatic pyrazole-containing carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds and also to a method of using these compounds for treating and/or inhibiting pain and further diseases and/or disorders.