1270921-49-7Relevant articles and documents
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
Trabanco, Andrés A.,Duvey, Guillaume,Cid, José María,MacDonald, Gregor J.,Cluzeau, Philippe,Nhem, Vanthea,Furnari, Rocco,Behaj, Nadia,Poulain, Géraldine,Finn, Terry,Lavreysen, Hilde,Poli, Sonia,Raux, Alexandre,Thollon, Yves,Poirier, Nicolas,DAddona, David,Andrés, José Ignacio,Lutjens, Robert,Poul, Emmanuel Le,Imogai, Hassan,Rocher, Jean-Philippe
, p. 971 - 976 (2011/03/21)
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration that led
