1270931-20-8

Basic information

• Product Name: 4-iodo-5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole
• Synonyms: 4-iodo-5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole
• CAS NO: 1270931-20-8
• Molecular Weight: 541.357
• Mol File: 1270931-20-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-iodo-5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-iodo-5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole(1270931-20-8)
• EPA Substance Registry System: 4-iodo-5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole(1270931-20-8)

Safety Data

• Hazardous Substances Data: 1270931-20-8(Hazardous Substances Data)

Upstream product

• 1270931-17-3 4-bromo-5-(4-methoxytetrahydropyran-4-yl)-2-(methylthio)thiazole 
• 210107-38-3 3-(4-iodophenyl)-3-(trifluoromethyl)-3H-diazirine 

Downstream Products

• 1270931-12-8 5-(4-methoxytetrahydropyran-4-yl)-2-(4-(3-trifluoromethyl-diazirin-3-yl)phenylthio)thiazole 
• 1270931-21-9 C₁₇H₁₅⁽²⁾HF₃N₃O₂S₂ 
• 1270931-13-9 C₁₇H₁₅⁽³⁾HF₃N₃O₂S₂ 

Relevant articles and documents

Synthesis of a tritium-labeled photo-affinity probe based on an atypical leukotriene biosynthesis inhibitor

A radiolabeled photo-affinity probe containing a diazirine group was designed and synthesized based on an atypical leukotriene (LT) biosynthesis inhibitor to determine whether this type of inhibitor (such as 5) interacts with a novel protein, critical for LT biosynthesis. One of the key transformations was to introduce a tritium label in the thiazole ring. This was eventually achieved by treating the iodinated compound with tritium, Pt/C (sulfided) and triethylamine in anhydrous aprotic solvent, to give the tritiated compound with a specific activity of 303 GBq/mmol. The affinity probe will be used to identify the proteins and protein complexes with which this type of molecules interacts with in inflammatory cells. Copyright 2010 John Wiley & Sons, Ltd. Synthesis of a high specific activity (303 GBq/mmol) tritium-labeled photo-affinity probe based on an atypical leukotriene biosynthesis inhibitor is described.