127095-96-9Relevant academic research and scientific papers
Polypeptide formation by heating N-t-butyloxycarbonyl acidic amino acid derivatives
Munegumi,Qing Meng,Harada
, p. 4716 - 4722 (2014)
An acid labile N-protecting group for amino acids, t-butyloxycarbonyl (Boc) group has deprotected at elevated temperatures. The study describes an application of the lability on heating to synthesis of polypeptides from acidic amino acids. t-Butyloxycarbonyl-acidic amino acids (aspartic acid, glutamic acid and β-aminoglutaric acid) and their anhydrides were heated at the higher temperatures than their melting points. Anhydrides of t-butyloxycarbonyl-aspartic acid and t-butyloxycarbonyl-β-aminoglutaric acid gave polypeptides. Thermal analyses of the substrates clarified the pathway of the polypeptide formation.
IONIZABLE COMPOUNDS AND COMPOSITIONS AND USES THEREOF
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Paragraph 0561; 0562, (2017/01/19)
This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.
2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS
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Page/Page column 64, (2010/02/08)
The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV having the formula I: (I) The invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of such compounds for the manufacture of medicaments for treating diseases that are associated with proteins which are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity.
Thermal Syntheses of Polypeptides from N-Boc-Amino Acid(Aspartic Acid,β-Aminoglutaric Acid) Anhydrides
Munegumi, Toratane,Meng, Yan-Quing,Harada, Kaoru
, p. 1643 - 1646 (2007/10/02)
N-t-Butyloxycarbonyl-amino acid(aspartic acid:Asp, glutamic acid:Glu, β-aminoglutaric acid: β-Agl)anhydrides were deprotected upon heating at temperatures slightly higher than the melting points of these compounds and polypeptides were synthesized easily in high yield.
Potential antitumor agents. 45. Synthesis, DNA-binding interaction, and biological activity of triacridine derivatives
Atwell,Baguley,Wilmanska,Denny
, p. 69 - 74 (2007/10/02)
A series of amide-linked triacridines of varying interchromophore separation were synthesized as potential DNA trisintercalating agents. The correseponding diamide diacridines (lacking the central chromophore) were also prepared, and the DNA-binding and b
