127102-48-1Relevant academic research and scientific papers
An amino acid coordinated vanadium (IV) complex: Synthesis, structure, DFT calculations and VHPO mimicking catalytic bromoperoxidation of organic substrates
Saha, Urmila,Si, Tapan Kr.,Nandi, Prasanta Kr.,Mukherjea, Kalyan K.
, p. 43 - 46 (2013)
A new VHPO mimicking oxovanadium(IV) complex [VO(sal-l-val)(phen)] (sal-l-val = Schiff base derived from salicylaldehyde and l-valine; phen = 1,10-phenanthroline) has been synthesized and characterized by elemental analysis, UV-vis, IR spectroscopy, ESI-MS, EPR and single crystal XRD studies. The structural and spectral parameters were further supported using DFT calculations. The complex was found to exhibit vanadium dependent haloperoxidase (VPHO) activity.
Synthesis, structural characterization and catalytic activity of a multifunctional enzyme mimetic oxoperoxovanadium(v) complex
Si, Tapan K.,Paul, Shiv S.,Drew, Michael G. B.,Mukherjea, Kalyan K.
scheme or table, p. 5805 - 5815 (2012/06/15)
The synthesis and structural characterization of a novel oxoperoxovanadium(v) complex [VO(O2)(PAH)(phen)] containing the ligands 2-phenylacetohydroxamic acid (PAHH) and 1,10-phenanthroline (phen) has been accomplished. The oxoperoxovanadium(v) complex was found to mimic both vanadate-dependent haloperoxidase (VHPO) activity as well as nuclease activity through effective interaction with DNA. The complex is the first example of a structurally characterized stable oxoperoxovanadium(v) complex with a coordinated bi-dentate hydroximate moiety (-CONHO-) from 2-phenylacetohydroximate (PAH). The oxoperoxovanadium(v) complex has been used as catalyst for the peroxidative bromination reaction of some unsaturated alcohols (e.g. 4-pentene-1-ol, 1-octene-3-ol and 9-decene-1-ol) in the presence of H2O2 and KBr. The catalytic products have been characterized by GC-MS analysis and spectrophotometric methods. The DNA binding of this complex has been established with CT DNA whereas the DNA cleavage was demonstrated with plasmid DNA. The interactions of the complex with DNA have been monitored by electronic absorption and fluorescence emission spectroscopy. Viscometric measurements suggest that the compound is a DNA intercalator. The nuclease activity of this complex was confirmed by gel electrophoresis studies.
