1271024-69-1Relevant academic research and scientific papers
Structure-based design of selective janus kinase 2 imidazo[4,5- d ]pyrrolo[2,3- b ]pyridine inhibitors
Hart, Amy C.,Schroeder, Gretchen M.,Wan, Honghe,Grebinski, James,Inghrim, Jennifer,Kempson, James,Guo, Junqing,Pitts, William J.,Tokarski, John S.,Sack, John S.,Khan, Javed A.,Lippy, Jonathan,Lorenzi, Matthew V.,You, Dan,Mcdevitt, Theresa,Vuppugalla, Ragini,Zhang, Yueping,Lombardo, Louis J.,Trainor, George L.,Purandare, Ashok V.
, p. 845 - 849 (2015)
Early hit to lead work on a pyrrolopyridine chemotype provided access to compounds with biochemical and cellular potency against Janus kinase 2 (JAK2). Structure-based drug design along the extended hinge region of JAK2 led to the identification of an imp
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms
Wan, Honghe,Schroeder, Gretchen M.,Hart, Amy C.,Inghrim, Jennifer,Grebinski, James,Tokarski, John S.,Lorenzi, Matthew V.,You, Dan,Mcdevitt, Theresa,Penhallow, Becky,Vuppugalla, Ragini,Zhang, Yueping,Gu, Xiaomei,Iyer, Ramaswamy,Lombardo, Louis J.,Trainor, George L.,Ruepp, Stefan,Lippy, Jonathan,Blat, Yuval,Sack, John S.,Khan, Javed A.,Stefanski, Kevin,Sleczka, Bogdan,Mathur, Arvind,Sun, Jung-Hui,Wong, Michael K.,Wu, Dauh-Rurng,Li, Peng,Gupta, Anuradha,Arunachalam,Pragalathan, Bala,Narayanan, Sankara,Nanjundaswamy,Kuppusamy, Prakasam,Purandare, Ashok V.
supporting information, p. 850 - 855 (2015/08/24)
JAK2 kinase inhibitors are a promising new class of agents for the treatment of myeloproliferative neoplasms and have potential for the treatment of other diseases possessing a deregulated JAK2-STAT pathway. X-ray structure and ADME guided refinement of C
JAK2 INHIBITORS AND THEIR USE FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND CANCER
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, (2011/04/14)
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of JAK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
