127107-23-7 Usage
General Description
1-methyl-1H-pyrazol-4-amine, also known as 1-methyl-4-pyrazolidinamine, is a synthetic organic compound with the chemical formula C4H8N4. It is a derivative of pyrazole and is commonly used as a building block in organic synthesis and pharmaceutical research. This chemical has been studied for its potential applications in the development of antiviral and anticancer drugs. It is also known to exhibit activity as an inhibitor of the enzyme caspase-3, which plays a role in apoptosis, or programmed cell death. Additionally, 1-methyl-1H-pyrazol-4-amine has been investigated for its potential as a stabilizer for nitrocellulose explosives and as an inhibitor of fatty acid amide hydrolase, an enzyme involved in the endocannabinoid system.
Check Digit Verification of cas no
The CAS Registry Mumber 127107-23-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,1,0 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 127107-23:
(8*1)+(7*2)+(6*7)+(5*1)+(4*0)+(3*7)+(2*2)+(1*3)=97
97 % 10 = 7
So 127107-23-7 is a valid CAS Registry Number.
127107-23-7Relevant articles and documents
Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation
Baldwin, Aaron F.,Caporello, Michaella A.,Chen, Guoyong,Goetz, Adam E.,Hu, Weifeng,Jin, Chengfeng,Knopf, Kevin M.,Li, Zhifeng,Lu, Cuong V.,Monfette, Sebastien,Puchlopek-Dermenci, Angela L. A.,Shi, Feng
, p. 1065 - 1073 (2021/05/04)
We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate. This procedure provides an alternative to the standard nitration/reduction sequence and avoids energetic intermediates, specialized hydrogenation equipment, and potentially genotoxic impurities that arise from nitro reduction. The chemistry has been successfully scaled to produce >50 kg of the target compound and demonstrate the viability of this alternative route.
