127107-23-7 Usage
Description
1-methyl-1H-pyrazol-4-amine, also known as 1-methyl-4-pyrazolidinamine, is a synthetic organic compound with the chemical formula C4H8N4. It is a derivative of pyrazole and is commonly used as a building block in organic synthesis and pharmaceutical research. This chemical has been studied for its potential applications in the development of antiviral and anticancer drugs, as well as for its ability to inhibit the enzyme caspase-3, which plays a role in apoptosis or programmed cell death.
Uses
Used in Pharmaceutical Research:
1-methyl-1H-pyrazol-4-amine is used as a building block in the development of antiviral and anticancer drugs due to its potential therapeutic properties.
Used in Enzyme Inhibition:
1-methyl-1H-pyrazol-4-amine is used as an inhibitor of the enzyme caspase-3, which is involved in the process of apoptosis or programmed cell death, making it a potential candidate for the development of treatments targeting cell death regulation.
Used in Explosive Stabilization:
1-methyl-1H-pyrazol-4-amine is used as a stabilizer for nitrocellulose explosives, enhancing their safety and performance.
Used in Endocannabinoid System Regulation:
1-methyl-1H-pyrazol-4-amine is used as an inhibitor of fatty acid amide hydrolase, an enzyme involved in the endocannabinoid system, which may have implications for the development of treatments targeting various physiological and pathological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 127107-23-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,1,0 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 127107-23:
(8*1)+(7*2)+(6*7)+(5*1)+(4*0)+(3*7)+(2*2)+(1*3)=97
97 % 10 = 7
So 127107-23-7 is a valid CAS Registry Number.
127107-23-7Relevant articles and documents
Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation
Baldwin, Aaron F.,Caporello, Michaella A.,Chen, Guoyong,Goetz, Adam E.,Hu, Weifeng,Jin, Chengfeng,Knopf, Kevin M.,Li, Zhifeng,Lu, Cuong V.,Monfette, Sebastien,Puchlopek-Dermenci, Angela L. A.,Shi, Feng
, p. 1065 - 1073 (2021/05/04)
We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate. This procedure provides an alternative to the standard nitration/reduction sequence and avoids energetic intermediates, specialized hydrogenation equipment, and potentially genotoxic impurities that arise from nitro reduction. The chemistry has been successfully scaled to produce >50 kg of the target compound and demonstrate the viability of this alternative route.
