127108-66-1

Basic information

• Product Name: 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI)
• Synonyms: 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI);4-Methyl-1,2,3-thiadiazole-5-carboxaldehyde;4-Methyl-1,2,3-thiadiazol-5-carbaldehyde
• CAS NO: 127108-66-1
• Molecular Formula: C₄H₄N₂OS
• Molecular Weight: 128.15236
• Product Categories: ALDEHYDE;Building Blocks;Thiazole
• Mol File: 127108-66-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 235.618 °C at 760 mmHg
• Flash Point: 96.298 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 0.0496mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI)(127108-66-1)
• EPA Substance Registry System: 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI)(127108-66-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 127108-66-1(Hazardous Substances Data)

Usage

General Description

1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI) is a chemical compound with the molecular formula C5H5N3OS. It is a heterocyclic organic compound that contains a thiadiazole ring and a carboxaldehyde group. 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI) is used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including antimicrobial and antifungal properties. Additionally, 1,2,3-Thiadiazole-5-carboxaldehyde, 4-methyl- (9CI) has been investigated for its potential as a fluorescent dye for detecting and labeling biological molecules in research and diagnostic applications.

InChI:InChI=1/C4H4N2OS/c1-3-4(2-7)8-6-5-3/h2H,1H3

Upstream product

• 163008-86-4 5-hydroxymethyl-4-methyl-1,2,3-thiadiazole 

Downstream Products

• 1063629-13-9 4-((4-methyl-1,2,3-thiadiazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one 
• 1383720-96-4 (E)-4-((4-methyl-1,2,3-thiadiazol-5-yl)methylene)-2-phenyloxazol-5(4H)-one 
• 1373252-86-8 C₁₄H₂₃N₇S 
• 1373252-89-1 C₁₄H₂₃N₇S 
• 1373252-80-2 C₁₄H₂₁N₇S 
• 1373252-82-4 C₁₅H₂₃N₇S 
• 1373252-88-0 C₁₅H₂₅N₇S 
• 1373252-85-7 C₁₅H₂₃N₇S 
• 1373252-84-6 C₁₆H₂₅N₇S 
• 1373252-78-8 C₁₇H₂₇N₇S 
• 1373252-79-9 C₁₇H₂₀FN₇S 
• 1373252-83-5 C₁₇H₂₀ClN₇S 
• 1373252-90-4 C₁₇H₂₀ClN₇S 
• 1373252-87-9 C₁₉H₂₅N₇S 

Relevant articles and documents

Synthesis and biological evaluation of 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives

To find new lead compounds with high biological activity, a series of novel 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR, IR spectrum and elemental analysis. Preliminary bioassay indicated that the title compounds exhibited moderate to strong fungicidal activity against six fungi in vitro at 50?μg/mL. Moreover, some of the title compounds exhibited good curative activity against TMV in vivo at 500?μg/mL. The structure-activity relationship analysis of compounds against Valsa mali showed that compounds containing halogen at the para position on phenyl exhibited the best activity. Especially compound 8k showed broad spectrum fungicidal activities against Valsa mali, Botrytis cinerea, Pythium aphanidermatum, Rhizoctonia solani, Fusarium moniliforme and Alternaria solani with the EC50 values of 8.20, 24.42, 15.80, 40.53, 41.48, and 34.16?μg/mL, respectively.

1,2,3-thiadiazole-containing benzoyl hydrazone derivative as well as preparation method and application thereof

The invention belongs to the field of organic compound synthesis and particularly relates to a 1,2,3-thiadiazole-containing benzoyl hydrazone derivative as well as a preparation method and application thereof. The structure of the compound is shown by a f

Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication

A series of new acrylamide derivatives containing 1,2,3-thiadiazole were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities in vitro. The IC50 of compounds 9b (10.4?μg/mL), 9c (3.59?μg/mL) and 17a (9.00?μg/mL) of the inhibition on the replication of HBV DNA were higher than that of the positive control lamivudine (14.8?μg/mL). Compound 9d exhibited significant activity against secretion of HBeAg (IC50?=?12.26?μg/mL).