1271193-41-9Relevant academic research and scientific papers
Facile synthesis of [1,2,3]-triazole-fused isoindolines, tetrahydroisoquinolines, benzoazepines and benzoazocines by palladium-copper catalysed heterocyclisation
Brahma, Kaushik,Achari, Basudeb,Chowdhury, Chinmay
supporting information, p. 545 - 555 (2013/04/10)
An elegant method for the synthesis of 1,2,3-triazoles fused with five-, six-, seven- and eight-membered benzoheterocycles, including isoindoline, tetrahydroisoquinoline, benzoazepine and benzoazocine, has been developed via palladium-copper catalysed reactions in one-pot. The broad scope of this reaction was illustrated by effecting bis-heteroannulations, synthesis of uracil derivatives of biological interest, and employment of acetylene gas as an inexpensive substrate. The reactions are experimentally simple and utilise easily accessible substrates of different types. Georg Thieme Verlag Stuttgart · New York.
Generation of medium-ring cycloalkynes by ring expansion of vinylogous acyl triflates
Tummatorn, Jumreang,Dudley, Gregory B.
supporting information; experimental part, p. 1572 - 1575 (2011/04/26)
Reductive cyclization of aryl and vinyl iodides tethered to vinylogous acyl triflates (VATs) induces a ring-expanding fragmentation to provide cyclic alkynyl ketones, including strained nine-membered cycloalkynes, in fair to excellent yield. The tandem cy
