1271214-54-0

Basic information

• Product Name: C₂₂H₂₁BrN₂O₃
• CAS NO: 1271214-54-0
• Molecular Weight: 441.324
• Mol File: 1271214-54-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁BrN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁BrN₂O₃(1271214-54-0)
• EPA Substance Registry System: C₂₂H₂₁BrN₂O₃(1271214-54-0)

Safety Data

• Hazardous Substances Data: 1271214-54-0(Hazardous Substances Data)

Upstream product

• 583-75-5 4-Bromo-2-methylaniline 

Relevant articles and documents

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor

Two new series of EP4 antagonists based on naphthalene/quinoline scaffolds have been identified as part of our on-going efforts to develop treatments for inflammatory pain. One series contains an acidic sulfonylurea pharmacophore, whereas the other is a neutral amide. Both series show subnanomolar intrinsic binding potency towards the EP4 receptor, and excellent selectivity towards other prostanoid receptors. While the amide series generally displays poor pharmacokinetic parameters, the sulfonylureas exhibit greatly improved profile. MF-592, the optimal compound from the sulfonylurea series, has a desirable overall preclinical profile that suggests it is suitable for further development.