127130-93-2

Upstream product

• 3143-02-0 3-hydroxymethyl-3-methyloxethane 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 

Downstream Products

• 127130-87-4 (2S,3aS,6aS,11bS)-3-(tert-Butyl-dimethyl-silanyl)-2-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-5-oxo-1,2,3,3a,4,5,6,6a-octahydro-pyrrolo[2,3-d]carbazole-7-carboxylic acid benzyl ester 
• 127130-80-7 (2S,3'S,5'S)-5'-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-(2-oxo-propyl)-4',5'-dihydro-spiro[indole-3,3'-pyrrole]-1-carboxylic acid benzyl ester 
• 127130-81-8 3-[(S)-2-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-2-((Z)-3-oxo-but-1-enylamino)-ethyl]-indole-1-carboxylic acid benzyl ester 
• 127130-94-3 [(S)-2-(1H-Indol-3-yl)-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Total synthesis of mannosyl tryptophan and its derivatives

Glycosylation is one of the most important post- or co-translational modifications of proteins, which affects the biological activities of the parent proteins by influencing the higher-order structure. Recently, a highly novel variant of glycoproteins tha

Asymmetric induction in the vinylogous amide photocycloaddition reaction. A formal synthesis of vindorosine

The application of the intramolecular vinylogous amide photocycloaddition/retro-Mannich fragmentation/Mannich closure sequence to a formal synthesis of vindorosine, 6, starting from L-tryptophan, is described. The synthesis of 7, which has been converted to vindorosine by Buchi, in 14 steps (7% overall yield from L-tryptophan) in homochiral form attests to the efficiency of this photochemical approach to the synthesis of the aspidosperma alkaloids, and demonstrates the exceedingly high levels of asymmetric induction which are possible via the intramolecular [2 + 2]photocycloaddition reaction of vinylogous amides.