127153-04-2

Usage

Uses

Used in Pharmaceutical Industry:
(+/-)-3-hydroxyphenylalanine phenylmethyl ester is used as a key intermediate in the synthesis of various pharmaceuticals and natural products. Its role in the development of new drugs is significant due to its ability to be incorporated into complex molecular structures.
Used in Neurological Disorder Treatment:
In the medical field, (+/-)-3-hydroxyphenylalanine phenylmethyl ester is studied for its potential therapeutic applications, particularly in the treatment of neurological disorders. Its unique structure allows it to interact with biological systems in ways that may alleviate symptoms or treat the underlying causes of these conditions.
Used as a Precursor in Organic Chemistry:
(+/-)-3-hydroxyphenylalanine phenylmethyl ester also serves as a valuable precursor for the synthesis of novel bioactive compounds. Its versatility as a building block enables the creation of a wide range of complex organic molecules with potential applications in various industries.
Used in Chemical Research:
In the realm of chemical research, (+/-)-3-hydroxyphenylalanine phenylmethyl ester is utilized for the exploration of new chemical reactions and mechanisms. Its unique properties make it an interesting subject for study, potentially leading to advancements in synthetic chemistry and material science.

Upstream product

• 775-06-4 D/L-3-hydroxy-phenylalanine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 127153-05-3 (+/-)-N-acetyl-3-hydroxyphenylalanine phenylmethyl ester 
• 127153-07-5 (+/-)-N-acetyl-3-(2-propenyl)phenylalanine phenylmethyl ester 
• 127153-06-4 (+/-)-N-acetyl-3-<<(trifluoromethyl)sulfonyl>oxy>phenylalanine phenylmethyl ester 
• 1313214-10-6 benzyl 2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propanoate 
• 300409-86-3 benzyl 3-(3-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate 
• 1313214-11-7 benzyl 2-amino-3-(3-(benzyloxy)phenyl)propanoate 
• 1313214-12-8 benzyl 3-(3-(benzyloxy)phenyl)-2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)propanoate 
• 1313214-13-9 2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid 

Relevant academic research and scientific papers

NEW INHIBITORS OF CYCLOPHILINS AND USES THEREOF

The present invention relates to a compound of formula (I): Formula (I), wherein: - n is 0, 1 or 2; - A is in particular CH or N; - X is in particular CO, SO2, CS, and R1 is in particular H, - R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, - R6 is in particular H or an alkyl group, and - R7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.

Carboxylic Acids and Tetrazoles as Isosteric Replacements for Sulfate in Cholecystokinin Analogues

A series of analogues of the satiely-inducing peptide cholecystokinin (CCK-8) was prepared in which the sulfated tyrosine required for activation of peripheral receptors was replaced with a carboxy(alkyl)- or tetrazolyl(alkyl)-phenylalanine to investigate whether an organic acid could serve the role of the sulfate group at the receptor.The necessary intermediates were prepared by previously reported procedures or by alkylation of carboxy(alkyl)- or tetrazolyl(alkyl)phenylmethyl bromides with a glycine-derived anion followed by protecting-group manipulations, and these were incorporated into derivatives of acetyl-CCK-7 using solid-phase synthesis.Peptide analogues were evaluated in a CCK-binding assay for affinity for either peripheral (CCK-B) receptors using homogenated rat pancreatic membranes as the receptor source or for central (CCK-B) receptors using bovine striatum as the receptor source.They were further evaluated for effects on food intake in rats after intraperitoneal (ip) injection.A number of the compounds reported are active in the CCK-A receptor binding assay although less potent than acetyl-CCK-7 and decrease food intake with comparable potency to acetyl-CCK-7.In a meal feeding model designed to assess appetite suppressant activity, acetyl-CCK-7 has an ED50 of 7 nmol/kg ip, while the ED50s of Ac-Phe(4-CH2CO2H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (28) and Ac-Phe-Met-Gly-Trp-Met-Asp-Phe-NH2 (34) were 9 and 11 nmol/kg ip, respectively.An analogue of 28 lacking the N-terminal acetamido group, 3-propanoyl-Met-Gly-Trp-Met-Asp-Phe-NH2 (50), was also active in the meal feeding assay with an ED50 of 3 nmol/kg ip.Its anorexic effect was blocked by simultaneous administration of the CCK-A receptor antagonist MK 329, indicating that the observed anorexic activity is mediated by CCK-A receptors.We conclude from this work that the requirement for a negative charge at the CCK-A receptor provided in the natural substrate by a sulfate group can be satisfied by organic acids.