127162-96-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Trifluoromethylbenzylsulfonyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals. Its strong electrophilic properties allow it to participate in multiple chemical reactions, contributing to the development of new drug molecules.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Trifluoromethylbenzylsulfonyl chloride serves as a building block in the synthesis of a wide range of agrochemicals. Its reactivity and ability to undergo multiple reactions make it a valuable component in the creation of effective agricultural chemicals.
Used in Fine Chemicals Production:
4-Trifluoromethylbenzylsulfonyl chloride is utilized in the production of fine chemicals due to its versatility and reactivity. It acts as a common reagent in organic synthesis, enabling the creation of various specialty chemicals for diverse applications.
Used in Organic Synthesis:
As a common reagent in organic synthesis, 4-Trifluoromethylbenzylsulfonyl chloride is used for its strong electrophilic properties, allowing it to undergo multiple chemical reactions. This makes it a valuable component in the synthesis of a wide range of important chemical compounds.

InChI:InChI=1/C8H6ClF3O2S/c9-15(13,14)5-6-2-1-3-7(4-6)8(10,11)12/h1-4H,5H2

Upstream product

• 124039-80-1 sodium 3-trifluoromethylbenzylsulfonate 

Downstream Products

• 874157-77-4 2-{methoxy-[1-(3-trifluoromethyl-phenylmethanesulfonylamino)-ethyl]-phosphinoylmethyl}-pentanedioic acid dimethyl ester 
• 124039-81-2 N-cyclopropyl-3-trifluoromethylbenzylsulfonamide 
• 1298109-22-4 C₁₄H₇F₈NO₂S 
• 1298109-33-7 C₁₉H₁₃F₈NO₄S 
• 1123754-41-5 (S)-1-(1H-indol-3-yl)-2-(3-trifluoromethyl-phenylmethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline 
• 1123754-35-7 (R)-1-(1H-indol-3-yl)-2-(3-trifluoromethylphenylmethanesulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 541528-51-2 [6-methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-acetic acid 
• 541528-50-1 [6-methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Alkyne Linchpin Strategy for Drug:Pharmacophore Conjugation: Experimental and Computational Realization of a Meta-Selective Inverse Sonogashira Coupling

The late-stage functionalization (LSF) of pharmaceutical and agrochemical compounds by the site-selective activation of C-H bonds provides access to diverse structural analogs and expands synthetically-accessible chemical space. We report a C-H functionalization LSF strategy that hinges on the use of an alkyne linchpin to assemble conjugates of sp2-rich marketed pharmaceuticals and agrochemicals with sp3-rich 3D fragments and natural products. This is accomplished through a template-assisted inverse Sonogashira reaction that displays high levels of selectivity for the meta position. This protocol is also amenable to distal structural modifications of α-amino acids. The transformation of alkyne functionality to other functional groups further highlights the applicative potential. Computational and experimental mechanistic studies shed light on the detailed mechanism. Turnover-limiting 1,2-migratory insertion of the bromoalkyne coupling partner occurs after relatively fast C-H activation. While this insertion occurs unselectively, regioconvergence results from one of the adducts undergoing a 1,2-trialkylsilyl migration to form the alkynylated product. A heterobimetallic Pd-Ag transition structure is essential for product formation in the β-bromide elimination step.

Arylmethylenesulfonamidoacetonitrile derivatives

Arylmethylenesulfonamidoacetonitrile derivatives. The compounds are useful as selective hericides especially with respect to the prevention and elimination of barnyardgrass in grass crops, especially rice.

Herbicidal arylmethylenesulfonamido-acetamide and thioacetamide derivatives

Arylmethylenesulfonamidoacetamide and thioacetamide derivatives and arylmethylenesulfonamidoester intermediates therefor. The compounds are useful as selective herbicides especially with respect to the prevention and elimination of barnyardgrass in grass