1271738-59-0 Usage
Description
MI-3 (Menin-MLL Inhibitor) is a small molecule inhibitor that targets the interaction between menin and mixed lineage leukemia (MLL) fusion proteins, playing a crucial role in the development and progression of certain types of leukemia.
Used in Pharmaceutical Industry:
MI-3 (Menin-MLL Inhibitor) is used as a therapeutic agent for the treatment of leukemia, specifically targeting MLL fusion proteins that drive oncogenic activity in the disease. It has demonstrated the ability to reverse the oncogenic activity of MLL fusion proteins, inhibit the growth of mouse bone marrow cells expressing MLL fusion proteins, and reduce colony formation and induce differentiation in MLL-AF9-transformed bone marrow cells.
Additionally, MI-3 has shown efficacy in inhibiting the growth of human leukemia cell lines containing MLL translocations and decreasing the expression of transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells, making it a promising candidate for further research and development in the fight against leukemia.
Check Digit Verification of cas no
The CAS Registry Mumber 1271738-59-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,1,7,3 and 8 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1271738-59:
(9*1)+(8*2)+(7*7)+(6*1)+(5*7)+(4*3)+(3*8)+(2*5)+(1*9)=170
170 % 10 = 0
So 1271738-59-0 is a valid CAS Registry Number.
