127180-77-2

Upstream product

• 127103-59-7 C₃₁H₃₈N₄O₈ 
• 82622-02-4 5-(benzyloxy)-2,4-dimethoxy-3-methylbenzaldehyde 
• 127103-52-0 1-Acetyl-3-(5-hydroxy-2,4-dimethoxy-3-methyl-benzyl)-piperazine-2,5-dione 
• 127103-51-9 1-Acetyl-3-[1-(5-benzyloxy-2,4-dimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-piperazine-2,5-dione 
• 127103-56-4 Carbonic acid (1S,3R)-1-[(R)-1-tert-butoxycarbonylamino-2-(5-tert-butoxycarbonyloxy-2,4-dimethoxy-3-methyl-phenyl)-ethyl]-3-hydroxymethyl-5,7-dimethoxy-2,6-dimethyl-1,2,3,4-tetrahydro-isoquinolin-8-yl ester tert-butyl ester 
• 127103-54-2 3-[1-(5-Benzyloxy-2,4-dimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-6-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2,5-dioxo-piperazine-1-carboxylic acid benzyl ester 
• 127103-55-3 (1R,9S)-12-[1-(5-Benzyloxy-2,4-dimethoxy-3-methyl-phenyl)-meth-(Z)-ylidene]-3-hydroxy-4,6-dimethoxy-5-methyl-10-oxo-11,13-diaza-tricyclo[7.3.1.0^2,7]trideca-2,4,6-triene-13-carboxylic acid benzyl ester 
• 127103-58-6 C₃₃H₄₄N₄O₈ 
• 127103-57-5 ((1S,3R,1'S,3'R)-8,8'-Dihydroxy-3-hydroxymethyl-5,7,5',7'-tetramethoxy-2,6,6'-trimethyl-1,2,3,4,1',2',3',4'-octahydro-[1,3']biisoquinolinyl-1'-ylmethyl)-carbamic acid tert-butyl ester 
• 127103-53-1 4-Acetyl-2-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-3,6-dioxo-piperazine-1-carboxylic acid benzyl ester 

Downstream Products

• 92569-03-4 (+)-saframycin F 
• 92569-02-3 (-)-saframycin G 
• 92569-02-3 (+)-5-epi-saframycin G 

Relevant academic research and scientific papers

A stereocontrolled total synthesis of (±)-saframycin A

A thirteen-step total synthesis of (±)-saframycin A from a tricyclic lactam intermediate is described. The key step of this total synthesis is the stereocontrolled construction of a pentacyclic saframycin framework via a modified Pictet-Spengler type cyclization generating a bis-carboxylic acid ester derivative, followed by decarboxylation. The cytotoxicity profiles are also presented.