127199-40-0

Basic information

• Product Name: 7-(R)-amino-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane
• Synonyms: 7-(R)-amino-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane
• CAS NO: 127199-40-0
• Molecular Weight: 216.326
• Mol File: 127199-40-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(R)-amino-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(R)-amino-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane(127199-40-0)
• EPA Substance Registry System: 7-(R)-amino-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane(127199-40-0)

Safety Data

• Hazardous Substances Data: 127199-40-0(Hazardous Substances Data)

Upstream product

• 127199-39-7 7-(R)-amino-5-<1(R)-phenylethyl>-4-oxo-5-azaspiro<2.4>heptane 

Downstream Products

• 127199-43-3 7(R)-<(tert-butoxycarbonyl)amino>-5-<1(R)-phenylethyl>-5-azaspiro<2.4>heptane 

Relevant articles and documents

(Fluorocyclopropyl)quinolones. 2. Synthesis and stereochemical structure- activity relationships of chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1- (2-fluorocyclopropyl)quinolone antibacterial agents

A series of novel chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro- 1-(2-fluorocyclopropyl)-quinolones were synthesized as a continuation of a research project of 1-(2-fluorocyclopropyl)-quinolones by considering stereochemical and physicochemical properties of the molecule. Absolute configurations of the 1-(cis-2-fluorocyclopropyl) moiety and the 7-(7-amino- 5-azaspiro-[2.4]heptan-5-yl) moiety were determined by X-ray crystallographic analysis. Stereochemical structure-activity relationship studies indicated that 1-[(1R,2S)-2-fluorocyclopropyl] and 7-[(7S)-amino-5-azaspiro[2.4]heptan- 5-yl] derivatives are more potent against Gram-positive and Gram-negative bacteria than the other stereoisomers and 7-[(7S)-7-amino-5-azaspiro[2.4]- heptan-5-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]quinolone (33) is the most potent of all stereoisomers. Pharmacokinetic profiles and physicochemical properties of the selected compounds were also examined, and it was found that 33 (DU-6859a) possesses moderate lipophilicity and good pharmacokinetic profiles.